Jordane Preto


Jordane Preto



        Doctor of Philosophy in Theoretical and Mathematical Physics
        Centre de Physique Théorique (CPT), Marseille, France

        Master of Science in Theoretical and Mathematical Physics
        Faculté des Sciences de Luminy, Université de la Méditerranée, Marseille, France

        Bachelor of Science in Theoretical Physics
        Université Henri Poincaré, Nancy, France





   My work is based on the development and the utilization of docking and molecular dynamics-based techniques in order to investigate the binding modes and affinities of molecular drugs to critical biological targets. Typical applications include (1) investigating the molecular mechanisms explaining the effects of anesthetics and psychoactive drugs on consciousness (2) finding new potent inhibitors to the NF-kappa-B-inducing kinase (3) developing advanced sampling methods to efficiently explore the binding free energy landscapes of protein-ligand complexes.

   I also developed a computational package MOBPredictor to facilitate the use of popular docking software. The package is particularly suitable to compare docking results obtained from different software and to combine them in a consensus docking or consensus scoring strategy.
MOB Predictor:





  1. Preto J. Semi-classical statistical description of Fröhlich condensation. J Biol Phys 2017; 43: 167–84.

  2. Nardecchia I, Torres J, Lechelon M, et al. Out-of-equilibrium collective oscillation as phonon condensation in a model protein 2017.

  3. Nardecchia I, Lechelon M, Gori M, et al. Detection of long-range electrostatic interactions between charged molecules by means of Fluorescence Correlation Spectroscopy 2017.

  4. Spasevska I, Ayoub A, Winter P, et al. Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin. Int J Mol Sci 2017; 18: 1676.

  5. Craddock TJA, Kurian P, Preto J, et al. Anesthetic Alterations of Collective Terahertz Oscillations in Tubulin Correlate with Clinical Potency: Implications for Anesthetic Action and Post-Operative Cognitive Dysfunction. Sci Rep 2017; 7: 9877.

  6. Preto J. Classical investigation of long-range coherence in biological systems. Chaos An Interdiscip J Nonlinear Sci 2016; 26: 123116.

  7. Tuszynski JA, Wenger C, Friesen DE, Preto J. An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields. Int J Environ Res Public Health 2016; 13: 1128.

  8. Preto J, Nardecchia I, Jaeger S, Ferrier P, Pettini M. Investigating encounter dynamics of biomolecular reactions: long-range resonant interactions versus Brownian collisions. Res Signpost 2015; 37661: 978–81.

  9. Preto J, Pettini M, Tuszynski JA. Possible role of electrodynamic interactions in long-distance biomolecular recognition. Phys Rev E 2015; 91: 52710.

  10. Nardecchia I, Spinelli L, Preto J, et al. Experimental detection of long-distance interactions between biomolecules through their diffusion behavior: Numerical study. Phys Rev E 2014; 90: 22703.

  11. Preto J, Clementi C. Fast recovery of free energy landscapes via diffusion-map-directed molecular dynamics. Phys Chem Chem Phys 2014; 16: 19181–91.

  12. Preto J, Pettini M. Resonant long-range interactions between polar macromolecules. Phys Lett Sect A Gen At Solid State Phys 2013; 377: 587–91.

  13. Preto J, Floriani E, Nardecchia I, Ferrier P, Pettini M. Experimental assessment of the contribution of electrodynamic interactions to long-distance recruitment of biomolecular partners: Theoretical basis. Phys Rev E 2012; 85: 41904.